Chiron

Chiron

Minimizes steric clashes in protein structures using short DMD simulations. Preserves backbone conformation while resolving atomic overlaps from homology models, low-resolution structures, and cryo-EM maps.

Gaia

Evaluates protein structure quality against high-resolution crystal benchmark data, providing per-metric p-values for clashes, hydrogen bonds, voids, geometry, and side chains.

How to cite Chiron and Gaia

If you use Chiron or Gaia in your work, please cite:

  1. Ramachandran S, Kota P, Ding F, Dokholyan NV. Automated minimization of steric clashes in protein structures. Proteins. 2011;79(1):261-270.doi:10.1002/prot.22879PubMed 21058396
  2. Kota P, Ding F, Ramachandran S, Dokholyan NV. Gaia: automated quality assessment of protein structure models. Bioinformatics. 2011;27(16):2209-2215.doi:10.1093/bioinformatics/btr374PubMed 21700672

Contact

For support or collaboration inquiries:

[email protected]